Sharbeen cancer research slc7a11
Webb13 maj 2024 · Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in Cancer Research, a journal of the American Association for Cancer Research. “Pancreatic cancer has seen minimal improvement in survival for the last four decades ... Webb20 apr. 2024 · Recent research suggests that cancer therapies, such as immunotherapy and radiotherapy, can induce ferroptosis partly through modulating SLC7A11 expression (Lang et al., 2024; Lei et al., 2024); knockout or inhibition of SLC7A11 has a significant inhibitory effect on lung cancer and pancreatic cancer cells (Ji et al., 2024; Sharbeen et …
Sharbeen cancer research slc7a11
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WebbThe vulnerability of ARID1A-deficient cancer cells results from low basal levels of GSH due to impaired expression of SLC7A11. The SLC7A11 -encoded cystine transporter supplies cells with cysteine, a key source of GSH, and its expression is enhanced by ARID1A-mediated chromatin remodeling. Thus, ARID1A-deficient cancers are susceptible to ... WebbSLC7A11为溶质载体家族成员之一，该基因编码胱氨酸/谷氨酸反转运体Xc-系统的轻链亚基 SLC7A11 (又称 xCT)。 通过介导胱氨酸摄取和谷氨酸释放促进谷胱甘肽的合成，保护细胞免受氧化应激，维持细胞的氧化还原平衡，阻止脂质过氧化诱导的细胞死亡。 SLC7A11在多种恶性肿瘤中过表达，与乳腺癌、卵巢癌、肝癌和肺癌等恶性肿瘤的生长、预后、转移和 …
Webb30 mars 2024 · Citation: Study shows cancers with high levels of the SLC7A11 gene may respond to glucose transporter inhibitor treatment (2024, March 30) retrieved 13 April … Webb12 maj 2024 · Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through protumor signaling and the …
WebbTargeting the undruggable in pancreatic cancer using nano-based gene silencing drugs. J Kokkinos, RMC Ignacio, G Sharbeen, C Boyer, E Gonzales-Aloy, ... Biomaterials 240, … Webb17 dec. 2024 · Ferroptosis, a regulated form of cell necrosis was previously reported to be induced upon pharmacological targeting of the cystine transporter SLC7A11 in Head …
Webb13 maj 2024 · SLC7A11 has been studied in pancreatic cancer cells before, but this is the first piece of research to show that it plays a critical role in non-tumour helper cells, too. …
WebbGeorge Sharbeen (0000-0002-6373-1930) George Sharbeen Activities Works (22) Sort Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit … how far is kenner la from houston txWebb28 juni 2024 · Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular components that comprise the TME can have a substantial impact on tumor progression and response to therapy. This collection features a sampling of recent studies published … how far is kenai from sewardWebb1 apr. 2024 · Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikin … how far is kenilworth from warwickWebb25 maj 2024 · SLC7A11 is also linked to neurological diseases 22,23,24,25,26, viral infections 27,28,29 and cancers 30,31, and drugs targeting SLC7A11 are being tested in … how far is kenly nc from meWebb13 maj 2024 · The team found a way to metabolically rewire tumours by targeting a protein called SLC7A11. ... said Dr George Sharbeen, a postdoc researcher who ... Medical Research Council, Cancer ... high back stool chairWebb12 juli 2024 · bioRxiv.org - the preprint server for Biology how far is kenner la from new orleans laWebb2 feb. 2024 · DOI: 10.1073/pnas.2024475118 Corpus ID: 231788830; Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11 @article{Mukhopadhyay2024AutophagyIR, title={Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11}, author={Subhadip … high back stacking garden chairs