Immunometabolism in the single-cell era
Witryna13 kwi 2024 · Immunometabolism the CyTOF way. In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8 + T cells metabolic … Witryna19 lut 2024 · Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4 + regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, their respective draining lymph nodes (LNs) and spleen. In these tissues, …
Immunometabolism in the single-cell era
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Witryna31 mar 2024 · Recent research about immunometabolism has contributed to the realization that stimuli and changes in the environment macrophages and DCs are exposed to, eventually converge into alterations in their metabolic properties. ... However, recent advances in single-cell technologies, such single-cell RNA sequencing and … WitrynaBut with the emergence of single-cell applications, researchers can now estimate the metabolic state of individual immune cells in clinical samples. Here, we review these …
Witryna30 wrz 2024 · → I am an accomplished researcher equipped with specialist expertise in metabolic disease and host-pathogen interactions, gained throughout my PhD and postdoctoral training. → As demonstrated by my publication record, I have a deep knowledge of tissue engineering, epigenetics, metabolism, immunity, and single … Witryna27 wrz 2024 · Metabolism as a driver of immunity. Immune cell activation initiates a programme of cell growth and differentiation, often coupled to proliferation. By the 1970s it was known that lymphocytes ...
Witryna4 lut 2024 · Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics. Adv Immunol. 2024;141:1–31. Article CAS PubMed Google Scholar Witryna3 lis 2024 · Single-cell metabolomics is currently too premature for large-scale applications, and thus alternate approaches are needed for immunometabolism …
Witryna5 lut 2024 · The macrophage is currently the prototypical cell studied in the immunometabolism field. ... the field is advancing rapidly with the development of novel tools and methods to dissect metabolism with single cell resolution (168, ... Van den Bossche J. Immunometabolism in the Single-Cell Era. Cell Metab (2024) …
Witryna15 kwi 2024 · Artyomov, M. N. & van den Bossche, J. Immunometabolism in the single-cell era. Cell Metab. 32 , 710–725 (2024). Article CAS PubMed PubMed Central … great whale river projectWitrynaAdvances in high-dimensional single-cell analyses and metabolic flux have improved our understanding of immunometabolism and brought the potential to identify new therapeutic strategies for cancer (Artyomov and den Bossche, 2024; Zhou et al., 2024). How best to translate these findings remains an open question, especially given the … great whale shogiWitryna13 kwi 2024 · In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8 + T cells metabolic changes at the single-cell level. This approach identified a transition state early in T cell activation that is characterized by high glycolytic and oxidative activity, providing new insight into the metabolic changes that underlie … florida resident halloween horror nightsWitrynaBut with the emergence of single-cell applications, researchers can now estimate the metabolic state of individual immune cells in clinical samples. Here, we review these … florida resident disney world ticketWitrynaEmerging research has identified metabolic pathways that are crucial for the proper regulation of immune cells and how, when deranged, they can cause immune … florida resident epcot tickets 1 dayWitrynaBut with the emergence of single-cell applications, researchers can now estimate the metabolic state of individual immune cells in clinical samples. Here, we review these single-cell techniques and their ability to validate common principles in immunometabolism, while also revealing context-dependent metabolic … florida resident discount orlando theme parksWitryna28 mar 2024 · Verberk et al. describe accessible, stepwise workflows for profiling mouse and human macrophage immunometabolism. Their toolbox integrates distinct metabolic and functional immune assays utilizing a 96-well plate format, providing a practical, semi-high-throughput approach to assess cellular metabolism of immune cells. florida resident disney ticket discount