Web2 de jun. de 2024 · Mutations in the EPAS1 HIF2α gene occur in the ODD domain. 但此时的化合物还不是其临床候选化合物。Peloton进一步通过基于结构的药物设计(SBDD)方 … Web12 de ago. de 2010 · The HIF2α puzzle. The transcriptional regulators hypoxia-inducible factor 1α ( HIF1α) and HIF2α are overexpressed in many cancers, and it has been suggested that the HIFs could be potential ...
HIF1α/HIF2α–Sox2/Klf4 promotes the malignant progression of ...
Web5 de out. de 2024 · VHL –/– ccRCC tumors and cell lines produce both HIF1α and HIF2α or HIF2α alone, which was an early clue that HIF2α has an important role in the … Web16 de fev. de 2024 · Inputs are shown in the bottom panels. N, JUP promoted the HIF2α-VHL interaction. 786-O cells were co-transfected with Flag-VHL (0.6 μg) and HA-JUP (0 or 1 μg) plasmids. Endogenous HIF2α co-immunoprecipitated with Flag antibody. Abbreviations: CHX, cycloheximide; JUP, junction plakoglobin green front manassas
HIF-1α信号通路 Abcam中文官网
Web27 de out. de 2024 · Abstract. Tumors driven by deficiency of the VHL gene product, which is involved in degradation of the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted inhibition of this pathway. Belzutifan, a highly specific and well-tolerated HIF2α inhibitor, recently received FDA approval for the treatment of … Web24 de ago. de 2024 · To investigate the function of HIF-2α in NLRP3 inflammasome activation, we analyzed whether genetic deficiency in Hif2α could affect the secretion of IL-1β and IL-18 in LPS-primed bone-marrow-derived macrophages (BMDMs) in response to specific NLRP3 inflammasome activators, including nigericin and ATP. BMDMs from … Web14 de dez. de 2012 · To address the role of the HIF2α-SLC7A5 pathway in tumor growth in vivo, we used the 786-O cellular model that has been widely used for assessing the protumoral properties of HIF2α in renal cell carcinoma (Kondo et al., 2003; Raval et al., 2005).For this purpose, we used 786-O-shSLC7A5 cells in which SLC7A5 expression … flush mount floor register laminate