WebThe teratogenicity of cyproheptadine HCL (Periactin) was studied in 3 groups of pregnant rats which received respectively 0.5 mg/kg/day, 2.5 mg/kg/day and 5 mg/kg/day cyproheptadine subcutaneously and in a control group of pregnant rats which received 0.2 ml/day of the solvent normal saline. Higher doses were toxic to pregnant rats. WebPregnancy: Pregnancy Category B. Reproduction studies have been performed in rabbits, mice and rats at oral or subcutaneous doses up to 32 times the maximum recommended human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to cyproheptadine. Cyproheptadine has been shown to be fetotoxic in rats when given …
Cyproheptadine (Cyproheptadine Hydrochloride): Uses, Dosage, …
WebLater 29 women with a total of 31 pregnancies were given 4 to 16 mg/day cyproheptadine HC1 for several months starting early in pregnancy. Previous study … Webcyproheptadine + clozapine. use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (incl. life-threatening), other anticholinergic adverse effects (additive effects) codeine. cyproheptadine (generic) +. codeine. 1 interaction. Avoid/Use Alternative. how far from nashville to clarksville tn
Cyproheptadine Monograph for Professionals - Drugs.com
WebJan 23, 2024 · Pregnancy. Category B. Lactation. Not known whether cyproheptadine is distributed into milk. Because of potential for serious adverse effects in nursing infants, discontinue nursing or the drug. (See Pediatric Use under Cautions.) Pediatric Use. Contraindicated in neonates and premature infants. WebCyproheptadine has been shown to be fetotoxic in rats when given by intraperitoneal injection in doses four times the maximum recommended human oral dose. Two studies in pregnant women, however, have not shown that cyproheptadine increases the risk of abnormalities when administered during the first, second and third trimesters of pregnancy. WebFeb 17, 2024 · Allergic conditions: Oral: Weight-directed or BSA-directed dosing: Children ≥2 years and Adolescents: 0.25 mg/kg/day or 8 mg/m 2 /day in 2 to 3 divided doses. Fixed-dosing: 2 to 6 years: 2 mg every 8 to 12 hours; maximum daily dose: 12 mg/ day. 7 to 14 years: 4 mg every 8 to 12 hours; maximum daily dose: 16 mg/ day. how far from nashville to destin fl