WebNov 7, 2024 · Cisplatin (cis-diamminedichloroplatinum (II)) is a square-planar geometry platinum coordination compound synthesized for the first time in 1844. Its cytotoxic properties were discovered in the 1970s and since its approval by FDA for cancer therapy in 1978 it has become one of the most commonly used drugs in the treatment of human … WebOct 1, 2024 · The Lysosomal pH shift induces nanofibril formation and lysosomal membrane permeation, thereby releasing the lysosomal contents into the cytoplasm and inducing LMP mediated cell death and cisplatin sensitization. Figure …
Cisplatin-induced cell death increases the degradation of …
WebOct 14, 2005 · Lysosomes are an essential part of the vesicular compartment and connect the outside medium with many classes of cellular targets in the cytosol, nucleus, … WebLysosomes have been proposed to sequester drugs, including cisplatin, and may therefore contribute to drug resistance. However, the mechanism(s) that facilitate this remains unclear. Our work demonstrates that the CACC TMEM16A drives lysosomal … We would like to show you a description here but the site won’t allow us. oohc meaning
Bafilomycin A1 increases the sensitivity of tongue squamous cell ...
WebBafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy. Author links open overlay panel Hong-Ying Chu a b 1, Wei Wang a 1, Xue Chen a, ... Lysosome is a potential target for increasing the cytotoxicity of DDP. WebApr 15, 2003 · Cisplatin (CP) is a component of standard treatment regimens for testicular, ovarian, bladder, cervical, head and neck and small-cell and nonsmall-cell lung cancers (Ozols and Williams, 1989 ... WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … iowa city catholic worker house