Cisplatin lysosomes

WebNov 7, 2024 · Cisplatin (cis-diamminedichloroplatinum (II)) is a square-planar geometry platinum coordination compound synthesized for the first time in 1844. Its cytotoxic properties were discovered in the 1970s and since its approval by FDA for cancer therapy in 1978 it has become one of the most commonly used drugs in the treatment of human … WebOct 1, 2024 · The Lysosomal pH shift induces nanofibril formation and lysosomal membrane permeation, thereby releasing the lysosomal contents into the cytoplasm and inducing LMP mediated cell death and cisplatin sensitization. Figure …

Cisplatin-induced cell death increases the degradation of …

WebOct 14, 2005 · Lysosomes are an essential part of the vesicular compartment and connect the outside medium with many classes of cellular targets in the cytosol, nucleus, … WebLysosomes have been proposed to sequester drugs, including cisplatin, and may therefore contribute to drug resistance. However, the mechanism(s) that facilitate this remains unclear. Our work demonstrates that the CACC TMEM16A drives lysosomal … We would like to show you a description here but the site won’t allow us. oohc meaning https://porcupinewooddesign.com

Bafilomycin A1 increases the sensitivity of tongue squamous cell ...

WebBafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy. Author links open overlay panel Hong-Ying Chu a b 1, Wei Wang a 1, Xue Chen a, ... Lysosome is a potential target for increasing the cytotoxicity of DDP. WebApr 15, 2003 · Cisplatin (CP) is a component of standard treatment regimens for testicular, ovarian, bladder, cervical, head and neck and small-cell and nonsmall-cell lung cancers (Ozols and Williams, 1989 ... WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … iowa city catholic worker house

Cisplatin remodels the tumor immune microenvironment …

Category:Lysosomes as mediators of drug resistance in cancer

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Cisplatin lysosomes

Monitoring autophagic flux by an improved tandem fluorescent …

WebNov 7, 2024 · Although cisplatin is one of the most common antineoplastic drug, its successful utilisation in cancer treatment is limited by the drug resistance. Multiple … WebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, cellular RNAs remain the most poorly characterized molecules.

Cisplatin lysosomes

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WebWestern blotting showed that cisplatin decreased protein expression of E6 and increased protein expression of p53, p21 and Bax. It had no effect on protein expression of Bcl-2. It is concluded that cisplatin can induce apoptosis in HeLa cells by suppressing HPV E6 and thereby restoring the function of p53. Publication types WebApr 22, 2003 · We isolated human KB adenocarcinoma cisplatin-resistant (CP-r) cell lines with multidrug-resistance phenotypes because of reduced accumulation of cisplatin and other cytotoxic compounds such as methotrexate and heavy metals.

WebMay 10, 2024 · This HIF/Ferritin axis is responsible for etoposide- and cisplatin-induced iron reduction in lysosomes and stemness of SCLC cells. This work demonstrates that …

WebSep 25, 2024 · We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with acquired chemoresistance. Cisplatin IC 50 in A549Pt (parental) and A549cisR (cisplatin resistant) cells was 13 μM and 47 μM, respectively. WebSep 21, 2015 · Platinum-based cisplatin is a first-line therapeutic agent used in the treatment of multiple cancers, including ovarian cancer. Cisplatin acts by inducing DNA damage, triggering cell cycle arrest, and initiating apoptosis ( 4 ). However, many ovarian cancer patients develop acquired cisplatin resistance, resulting in failure of …

WebLysosome Fe 2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells Iron metabolism has been shown to hand over cancer stem cell, which is regarded as the root of tumor progression, recurrence and chemoresistance.

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. oohc national standardsWebDec 8, 2024 · Cisplatin, activated by intracellular hydrolysis of chlorides, binds to DNA to form monoadducts as well as intra- and interstrand DNA cross-links [ 3 ]. As a result, it … iowa city chess clubWebLysosomes are specialized organelles for protein recycling and as such are involved in the terminal steps of autophagy. However, it has become evident that lysosomes also play an important role in the progression of apoptosis. iowa city cell phone repairWebJan 1, 2016 · Ctr1 imports platinum-based drugs into the cell. The drug enters the nucleus, induces DNA crosslinking, resulting in DNA damage, cell cycle arrest and apoptosis (a). … oohc outcomes frameworkWebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, … iowa city buy used carsWebAug 3, 2024 · The eukaryotic endomembrane system (EMS) is a set of interrelated membrane-bound organelles that include the endoplasmic reticulum (ER), Golgi, lysosome and the plasma membrane, as well as the vesicles trafficking between them. It is responsible for numerous cellular processes, such as endocytosis and exocytosis. iowa city cedar rapids corridorWebMar 1, 2024 · Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying the development of such chemoresistance, we comparatively analyzed established … iowa city car accident today