WebMar 6, 2024 · When antidepressants increase the availability of serotonin, they can inadvertently trigger vasoconstriction. This, in turn, causes blood pressure to rise. The effect on blood pressure can increase and decrease in tandem with the concentration of antidepressants in the bloodstream. Effect of SSRIs vs. Other Antidepressants WebBupropion and Blood Pressure. I just started Voxra 150mg Bupropion today. My blood pressure has gone from 128/78 two weeks ago to 148/88 today. I also feel sweaty and shakey. I have been drinking decent amounts of coffee (~7 cups throughout the day, normal for me) and smoking maybe once every two hours.
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